substance
noun(sub-stance)
the property of holding together and retaining its shape
substance
noun(sub-stance)
considerable capital (wealth or income)
substance
noun(sub-stance)
the idea that is intended
substance
noun(sub-stance)
what a communication that is about something is about
substance
noun(sub-stance)
the choicest or most essential or most vital part of some idea or experience
Synonyms: center, 
centre, 
core, 
essence, 
gist, 
heart, heart and soul, 
inwardness, 
kernel, 
marrow, 
meat, nitty-gritty, 
nub, 
pith, 
sum, 
 substance
noun(sub-stance)
a particular kind or species of matter with uniform properties
Examples:
Shigella is one of the most toxic substances known to man. 
substance
noun(sub-stance)
material of a particular kind or constitution
Examples:
The immune response recognizes invading substances. 
substance
noun(sub-stance)
the real physical matter of which a person or thing consists
Examples:
DNA is the substance of our genes.